I'm always looking for ways to effectively monetize my site. Adsense hasn't been too terribly successful for me and I suspect--with advice from my brother--that a big part has been placement. I have been placing Adsense ads in the right column, a little too low and in the footer.

Placing Adsense ads in the left and right columns and the footer in Drupal is easy. You can come up with the code in your Adsense account and then create a block with that information in it. No brainer.

Placing ads in nodes is another thing altogether. You could manually place an ad every time, but that does not seem like an effective way of placing ads.